There is strong evidence that insulin-like growth factor (IGF) signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high affinity IGF binding proteins, proteinases and endogenous inhibitors that all, along with their biological context, must be considered. The IGF system components are evolutionarily conserved, underscoring the importance of understanding this system in physiology and pathophysiology. This review will briefly describe the different components of the IGF system and then discuss past and current literature regarding the IGFs and aging, with a focus on cellular senescence, model organisms of aging, centenarian genetics, and three age-related diseases - pulmonary fibrosis, Alzheimer's disease, and macular degeneration - in appropriate murine models and in humans. Commonalities in mechanism suggest conditions where IGF system components may be disease drivers and potential targets in promoting healthy aging in humans.

中文翻译：

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胰岛素样生长因子系统和衰老。


有强有力的证据表明，胰岛素样生长因子 （IGF） 信号传导与衰老过程的基本方面有关。然而，IGF 系统的细胞外部分与各种受体、配体效应子、高亲和力 IGF 结合蛋白、蛋白酶和内源性抑制剂复杂，必须考虑所有这些及其生物学背景。IGF 系统成分在进化上是保守的，强调了在生理学和病理生理学中了解该系统的重要性。本综述将简要描述 IGF 系统的不同组成部分，然后讨论有关 IGF 和衰老的过去和现在的文献，重点是细胞衰老、衰老模式生物、百岁遗传学和三种与年龄相关的疾病 - 肺纤维化、阿尔茨海默病和黄斑变性 - 在适当的小鼠模型和人类中。机制的共性表明 IGF 系统成分可能成为促进人类健康老龄化的疾病驱动因素和潜在目标的条件。