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Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
Allergy ( IF 12.6 ) Pub Date : 2024-10-17 , DOI: 10.1111/all.16343 Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis
Allergy ( IF 12.6 ) Pub Date : 2024-10-17 , DOI: 10.1111/all.16343 Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis
Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial. The “epithelial barrier theory” suggests that genetic predisposition and exposure to diverse factors damaging the epithelial barriers contribute to the emergence of allergic and autoimmune conditions. Impaired epithelial barriers, microbial dysbiosis, and tissue inflammation have been observed in a high number of mucosal inflammatory, autoimmune and neuropsychiatric diseases, many of which showed increased prevalence in the last decades. Pets, especially cats and dogs, share living spaces with humans and are exposed to household cleaners, personal care products, air pollutants, and microplastics. The utilisation of cosmetic products and food additives for pets is on the rise, unfortunately, accompanied by less rigorous safety regulations than those governing human products. In this review, we explore the implications of disruptions in epithelial barriers on the well‐being of companion animals, drawing comparisons with humans, and endeavour to elucidate the spectrum of diseases that afflict them. In addition, future research areas with the interconnectedness of human, animal, and environmental well‐being are highlighted in line with the “One Health” concept.
中文翻译:
伴侣动物的上皮屏障功能障碍和相关疾病:人类与动物的异同和研究需求
自 1960 年代以来,超过 350,000 种新化学物质被引入人类和家畜的生活。其中许多已成为现代生活的一部分,有些则作为污染物影响自然。然而,我们对它们对人类和动物的潜在健康风险的理解仍然不完整。“上皮屏障理论”表明,遗传易感性和暴露于破坏上皮屏障的各种因素会导致过敏和自身免疫性疾病的出现。在大量粘膜炎症、自身免疫和神经精神疾病中观察到上皮屏障受损、微生物菌群失调和组织炎症,其中许多疾病在过去几十年中患病率增加。宠物,尤其是猫和狗,与人类共享生活空间,并接触家用清洁剂、个人护理产品、空气污染物和微塑料。不幸的是,宠物化妆品和食品添加剂的使用正在增加,但伴随着的安全法规不如管理人类产品的安全法规严格。在这篇综述中,我们探讨了上皮屏障破坏对伴侣动物福祉的影响,与人类进行比较,并努力阐明折磨它们的疾病谱。此外,根据“同一个健康”概念,强调了人类、动物和环境福祉相互关联的未来研究领域。
更新日期:2024-10-17
中文翻译:
伴侣动物的上皮屏障功能障碍和相关疾病:人类与动物的异同和研究需求
自 1960 年代以来,超过 350,000 种新化学物质被引入人类和家畜的生活。其中许多已成为现代生活的一部分,有些则作为污染物影响自然。然而,我们对它们对人类和动物的潜在健康风险的理解仍然不完整。“上皮屏障理论”表明,遗传易感性和暴露于破坏上皮屏障的各种因素会导致过敏和自身免疫性疾病的出现。在大量粘膜炎症、自身免疫和神经精神疾病中观察到上皮屏障受损、微生物菌群失调和组织炎症,其中许多疾病在过去几十年中患病率增加。宠物,尤其是猫和狗,与人类共享生活空间,并接触家用清洁剂、个人护理产品、空气污染物和微塑料。不幸的是,宠物化妆品和食品添加剂的使用正在增加,但伴随着的安全法规不如管理人类产品的安全法规严格。在这篇综述中,我们探讨了上皮屏障破坏对伴侣动物福祉的影响,与人类进行比较,并努力阐明折磨它们的疾病谱。此外,根据“同一个健康”概念,强调了人类、动物和环境福祉相互关联的未来研究领域。