Despite the prolonged therapeutic benefits offered by many existing extended-release oral drug formulations, their inability to conform to circadian rhythms and specific pathological profiles remains a critical limitation. Here, we report drug origami, a computation-guided, origami-inspired approach for modulating the drug release kinetics of oral formulations. By harnessing the precise folding patterns of origami, the drug origami demonstrates characteristics of pulsatile and multiphasic release that can be tailored to match specific medication regimens. By employing computational models guided by control equations, both in vitro and in vivo drug release kinetics can be predicted and modulated with good quantitative agreement. This and other evidence suggest drug origami to be “do-it-yourself” drugs in personalized medicine where patients can create their own formulations according to individual medical needs.

中文翻译：

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药物折纸：一种用于口服制剂可定制药物释放动力学的计算指导方法


尽管许多现有的缓释口服药物制剂提供了长期的治疗益处，但它们无法符合昼夜节律和特定的病理特征仍然是一个关键的限制。在这里，我们报告了药物折纸，这是一种计算引导的、受折纸启发的方法，用于调节口服制剂的药物释放动力学。通过利用折纸的精确折叠模式，药物折纸表现出搏动和多相释放的特性，可以定制以匹配特定的药物治疗方案。通过采用由控制方程指导的计算模型， 可以预测和调节体外和 体内药物释放动力学，具有良好的定量一致性。这一证据和其他证据表明，药物折纸是个性化医疗中的“自己动手”药物，患者可以根据个人医疗需求创建自己的配方。