The dynamic regional accuracy of electrical impedance tomography has not yet been validated. We aimed to compare the regional accuracy of electrical impedance tomography with that of four-dimensional computed tomography during dynamic ventilation. This single-center, prospective, observational study conducted in a general intensive care unit included adult patients receiving mechanical ventilation from July 2021 to February 2024. The patients were mechanically ventilated passively and underwent electrical impedance tomography and four-dimensional computed tomography on the same day. Overall, 45 patients were analyzed. The correlation coefficients in regional dynamic ventilation between four-dimensional computed tomography and electrical impedance tomography in each region were 0.963, 0.963, 0.835 (ventral, central, and dorsal, respectively) in the right lung and 0.947, 0.927, 0.823 (ventral, central, and dorsal, respectively) in the left lung. The correlation coefficient was low when the regional ventilation distribution detected by the electrical impedance tomography was < 2%. After excluding nine patients with a regional ventilation distribution of < 2%, the ventral, central, and dorsal correlation coefficients were 0.963, 0.963, and 0.946 in the right lung and 0.942, 0.924, and 0.951, respectively, in the left lung. Regional ventilation using electrical impedance tomography during dynamic ventilation was highly accurate and consistent with the time phase compared to four-dimensional computed tomography. Given the high correlation between these modalities, they can contribute significantly to further studies on regional ventilation dynamics. Trial registration number ClinicalTrials.gov (No. UMIN00044386).

中文翻译：

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用四维计算机断层扫描验证电阻抗断层扫描的区域通气动力学：单中心、前瞻性、观察性研究


电阻抗断层扫描的动态区域精度尚未得到验证。我们旨在比较动态通气期间电阻抗断层扫描与四维计算机断层扫描的区域准确性。这项在普通重症监护病房进行的单中心前瞻性观察性研究包括 2021 年 7 月至 2024 年 2 月接受机械通气的成年患者。患者采用被动机械通气，当天行电阻抗断层扫描和四维计算机断层扫描。总共分析了 45 例患者。各区域四维计算机断层扫描与电阻抗断层扫描的区域动态通气相关系数分别为 0.963、0.963、0.835 （分别为腹侧、中央和背侧），左肺为 0.947、0.927、0.823 （分别为腹侧、中央和背侧）。当电阻抗断层扫描检测到的区域通气分布为 < 2% 时，相关系数较低。排除 9 例区域通气分布为 < 2% 的患者后，右肺腹侧、中央侧和背侧相关系数分别为 0.963 、 0.963 和 0.946 ，左肺 分别为 0.942 、 0.924 和 0.951。与四维计算机断层扫描相比，在动态通气期间使用电阻抗断层扫描的区域通气高度准确且与时间相位一致。鉴于这些模式之间的高度相关性，它们可以为进一步研究区域通气动力学做出重大贡献。试验注册号 ClinicalTrials.gov （编号UMIN00044386）。