Solid epithelial cancers with significant desmoplasia are characterized by an excessive deposition of collagen-based matrix, which often supports tumor progression. However, the mechanism of how collagen receptors mediate collagen fibrillogenesis still remains mostly unclear.

中文翻译：

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成纤维细胞整合素 α11β1 是机械调节的原纤维粘附中的胶原蛋白组装受体


具有显著结缔组织增生的实体上皮癌的特征是基于胶原蛋白基质的过度沉积，这通常支持肿瘤进展。然而，胶原受体如何介导胶原纤维形成的机制仍不清楚。