We would like to thank Mertzlufft for raising the issue of importance of the physiological composition of crystalloid fluids [1]. In the process of guideline generation, we selected questions with sufficient clinical evidence to support a recommendation [2]. In that regard, we have addressed the question of the balanced crystalloids versus saline, for which multiple randomized clinical trials have been conducted. As highlighted in the guideline document and the article by Mertzlufft et al., there is limited clinical evidence to support other questions about the composition of different balanced crystalloids [3]. This point has been highlighted in the guidelines as an area for further research [2].

中文翻译：

---

复苏液的选择 — 离子组成很重要。作者的回复


我们要感谢 Mertzlufft 提出晶体液生理成分的重要性问题 [1]。在指南制定过程中，我们选择了具有足够临床证据来支持推荐的问题 [2]。在这方面，我们已经解决了平衡晶体与盐水的问题，为此已经进行了多项随机临床试验。正如指南文件和 Mertzlufft 等人的文章中所强调的那样，支持不同平衡晶体组成的其他问题的临床证据有限 [3]。这一点在指南中已被强调为进一步研究的领域 [2]。