Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking. With the Department of Physiology and Pharmacology now celebrating its 75-year anniversary, we wanted to take this as an opportunity to showcase recent research achievements and how they paved the way for current activities at the department. We emphasize examples from preclinical and clinical research where the dpartment's integrative environment and robust infrastructure have successfully facilitated the translation of findings into clinical applications and patient benefits. The close collaboration between preclinical scientists and clinical researchers across various disciplines, along with a strong network of partnerships within the department and beyond, positions us to continue leading world-class pharmacological research at the Department of Physiology and Pharmacology for decades to come.

中文翻译：

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卡罗林斯卡医学院生理学和药理学系成立 75 周年——近期成就和未来展望


卡罗林斯卡医学院是一所医科大学，包括 21 个系，分布在三个系或校区组。该研究所的药理学研究有着悠久而成功的传统，在血管舒张的神经元控制、心血管药理学、神经精神药理学、受体药理学和药物基因组学领域取得了大量开创性的发现，其中包括许多其他认可，其中包括生理学和医学领域的两项诺贝尔奖，一项于 1970 年授予 Ulf von Euler，以表彰他发现储存所涉及的过程。 神经递质的释放和失活，另一个于 1982 年授予 Sune Bergström 和 Bengt Samuelsson，以表彰他们在前列腺素和白三烯发现方面的工作。卡罗林斯卡医学院的药理学在过去十年中一直位列全球前 10 名，根据 QS 世界大学排名。随着生理学和药理学系现在庆祝其成立 75 周年，我们想以此为契机展示最近的研究成果以及它们如何为该系当前的活动铺平道路。我们强调临床前和临床研究的例子，其中该部门的综合环境和强大的基础设施成功地促进了研究结果转化为临床应用和患者利益。跨学科的临床前科学家和临床研究人员之间的密切合作，以及系内外强大的合作伙伴关系网络，使我们能够在未来几十年继续在生理学和药理学系领导世界一流的药理学研究。