Membrane lipid composition is maintained by conserved lipid transfer proteins, but computational approaches to study their lipid-binding mechanisms are limiting. Srinivasan et al. (https://doi.org/10.1083/jcb.202312055) develop a clever molecular dynamics simulations assay to accurately model lipid-binding poses in lipid transfer proteins.

中文翻译：

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使脂质非常不高兴发现它们如何与蛋白质结合。


膜脂质组成由保守的脂质转移蛋白维持，但研究其脂质结合机制的计算方法有限。Srinivasan 等人 （https://doi.org/10.1083/jcb.202312055） 开发了一种巧妙的分子动力学模拟分析，以准确模拟脂质转移蛋白中的脂质结合姿势。