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Calcineurin inhibitor blocks tolerance by suppressing donor T cell terminal exhaustion after allogeneic hematopoietic cell transplantation
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2024 , DOI: 10.1172/jci184332
Hajime Senjo, Daigo Hashimoto, Takanori Teshima

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD
Yewei Wang, … , Ping Zhang, Geoffrey R. Hill Yewei Wang, … , Ping Zhang, Geoffrey R. Hill Calcineurin inhibition mitigates exhaustion and rescues alloreactive central memory T cells in mice following bone marrow transplant. Research Article Immunology Transplantation


中文翻译:


钙调磷酸酶抑制剂通过抑制同种异体造血细胞移植后供体 T 细胞末端耗竭来阻断耐受性



钙调磷酸酶抑制可挽救促进慢性 GVHD 的同种异体抗原特异性中枢记忆 T 细胞亚群 Yewei Wang, ... , Ping Zhang, Geoffrey R. Hill Yewei Wang, ... , Ping Zhang, Geoffrey R. Hill 钙调磷酸酶抑制可减轻骨髓移植后小鼠的疲劳并挽救同种异体反应性中枢记忆 T 细胞。研究论文 免疫学 移植
更新日期:2024-10-16
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