Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance. Uncontrolled periodontal infections are the leading cause of tooth loss in adults. Thrombotic diseases can lead to partial or complete obstruction of blood flow in the circulatory system, manifesting as organ or tissue ischemia and necrosis in patients with arterial thrombosis, and local edema, pain and circulatory instability in patients with venous thrombosis, which may lead to mortality or fatality in severe case. Recent studies found that periodontitis might enhance thrombosis through bacterial transmission or systemic inflammation by affecting platelet-immune cell interactions, as well as the coagulation, and periodontal therapy could have a prophylactic effect on patients with thrombotic diseases. In this review, we summarized clinical findings on the association between periodontitis and thrombotic diseases and discussed several novel prothrombotic periodontitis-related agents, and presented a perspective to emphasize the necessity of oral health management for people at high risk of thrombosis.

牙周炎是一种由生物膜微生物引发并由宿主免疫失衡介导的慢性炎症性疾病。不受控制的牙周感染是成人牙齿脱落的主要原因。血栓性疾病可导致循环系统血流部分或完全阻塞，动脉血栓患者表现为器官或组织缺血和坏死，静脉血栓患者表现为局部水肿、疼痛和循环不稳定，严重时可导致死亡或死亡。最近的研究发现，牙周炎可能通过影响血小板-免疫细胞相互作用和凝血，通过细菌传播或全身炎症增强血栓形成，牙周治疗可能对血栓性疾病患者有预防作用。在本综述中，我们总结了牙周炎与血栓性疾病之间关联的临床发现，并讨论了几种新型的促血栓形成性牙周炎相关药物，并提出了强调血栓形成高危人群口腔健康管理必要性的观点。