Magnesium (Mg) stands out in temporary biomaterial applications due to its biocompatibility, biodegradability, and low Young's modulus. However, controlling its corrosion through next-generation polymer-based functional coatings is crucial due to the rapid degradation behavior of Mg. In this study, the function of 2D lamellar Ti3C2Tx (MXene) in Hydroxyapatite (HA) and Halloysite nanotube (HNT) hybrid coatings in biodegradable poly– (lactic acid) (PLA) was investigated. The morphological and structural characterizations of the coatings on Mg were revealed through HRTEM, XPS, SEM-EDX, XRD, FTIR, and contact angle analyses/tests. Electrochemical in vitro corrosion tests (OCP, PDS, and EIS-Nyquist) were conducted for evaluate corrosion resistance under simulated body fluid (SBF) conditions. The bioactivity of the coatings in SBF have been revealed in accordance with the ISO 23,317 standard. Finally, antibacterial disk diffusion tests were conducted to investigate the functional effect of MXene in coatings. It has been determined that the presence of MXene in the coating increased not only surface wettability (131°, 85°, 77°, and 74° for uncoated, pH, PHH, and PHH/MXene coatings, respectively) but also increased corrosion resistance (1857.850, 42.357, 1.593, and 0.085 × 10–6, A/cm2 for uncoated, pH, PHH, and PHH/MXene coatings, respectively). It has been proven that the in vitro bioactivity of PLA-HA coatings is further enhanced by adding HNT and MXene, along with SEM morphologies after SBF. Finally, 2D lamellar MXene-filled coating exhibits antibacterial behavior against both E. coli and S. aureus bacteria.

中文翻译：

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Ti3C2Tx MXene 功能化羟基磷灰石/埃洛石纳米管填充镁上的聚（乳酸）涂层：体外和抗菌应用


镁 （Mg） 因其生物相容性、生物降解性和低杨氏模量而在临时生物材料应用中脱颖而出。然而，由于 Mg 的快速降解行为，通过下一代基于聚合物的功能涂层来控制其腐蚀至关重要。在本研究中，研究了 2D 层状 Ti3C2Tx （MXene） 在可生物降解的聚乳酸 （PLA） 中的羟基磷灰石 （HA） 和埃洛石纳米管 （HNT） 杂化涂层中的功能。通过 HRTEM、XPS、SEM-EDX、XRD、FTIR 和接触角分析/测试揭示了 Mg 涂层的形态和结构特征。进行电化学体外腐蚀测试 （OCP、PDS 和 EIS-Nyquist） 以评估在模拟体液 （SBF） 条件下的耐腐蚀性。SBF 中涂层的生物活性已根据 ISO 23,317 标准进行披露。最后，进行抗菌圆盘扩散试验，探讨 MXene 在涂料中的功能影响。已经确定，涂层中 MXene 的存在不仅增加了表面润湿性（无涂层、pH、PHH 和 PHH/MXene 涂层分别为 131°、85°、77° 和 74°），而且还增加了耐腐蚀性（无涂层、pH、PHH 和 PHH/MXene 涂层分别为 1857.850、42.357、1.593 和 0.085 × 10-6、A/cm2）。已经证明，在 SBF 后添加 HNT 和 MXene 以及 SEM 形态进一步增强了 PLA-HA 涂层的体外生物活性。最后，2D 层状 MXene 填充涂层对大肠杆菌和金黄色葡萄球菌均表现出抗菌作用。