Due to its high heterogeneity and significant impact on women's health globally, breast cancer necessitates robust preclinical models to understand tumor biology and guide personalized treatment strategies. Three-dimensional (3D) in vitro tumor models hold immense promise in this regard. These tumor models not only mimic the spatial structure and growth environment of tumors in vivo, but also retain the pathological and genetic characteristics of solid tumors. This fidelity makes them powerful tools for accelerating advancements in fundamental research and translational medicine. The diversity, modularity, and efficacy of 3D tumor models are driving a biotechnological revolution. As these technologies become increasingly sophisticated, 3D tumor models are poised to become powerful weapons in the fight against breast cancer. This article expounds on the progress made in utilizing 3D tumor models for breast cancer research.

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3D肿瘤模型在乳腺癌中的应用与进展


由于其高度异质性并对全球女性健康产生重大影响，乳腺癌需要强大的临床前模型来了解肿瘤生物学并指导个性化治疗策略。三维 （3D） 体外肿瘤模型在这方面具有巨大的前景。这些肿瘤模型不仅模拟了体内肿瘤的空间结构和生长环境，还保留了实体瘤的病理和遗传特征。这种保真度使它们成为加速基础研究和转化医学进步的强大工具。3D 肿瘤模型的多样性、模块化和有效性正在推动一场生物技术革命。随着这些技术变得越来越复杂，3D 肿瘤模型有望成为对抗乳腺癌的有力武器。本文阐述了利用 3D 肿瘤模型进行乳腺癌研究的进展。