Heart failure is the leading cause of morbidity and mortality in adults with congenital heart disease. However, for many in this population, heart transplantation is not possible or requires longer wait times, necessitating prolonged circulatory support. The medium to long-term durable ventricular assist device therapy provides a possible solution. We analyzed outcomes of 9 patients with congenital heart disease and at least 3 years of durable mechanical support, all age 18 or older at the time of ventricular assist device implantation at our affiliated pediatric and adult hospitals. Palliated congenital anatomies varied and included biventricular physiologies as well as single ventricles with Fontan circulation. The median duration of support was 4.2 years, including 3 patients successfully bridged to transplant, averaging 2.1 years on the waitlist. Device-related complications were infrequent with HeartMate 3, a feasible and sustainable option for either bridge to transplant or destination strategies in adults with congenital heart disease.

中文翻译：

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成人先天性心脏病的中长期心室辅助装置支持。


心力衰竭是先天性心脏病成人发病率和死亡率的主要原因。然而，对于这一人群中的许多人来说，心脏移植是不可能的或需要更长的等待时间，因此需要长时间的循环支持。中长期持久心室辅助装置治疗提供了一种可能的解决方案。我们分析了 9 名先天性心脏病患者和至少 3 年持久机械支持的结果，这些患者在我们的附属儿科和成人医院植入心室辅助装置时均年满 18 岁。姑息性先天性解剖结构多种多样，包括双心室生理学以及具有 Fontan 循环的单心室。支持时间的中位数为 4.2 年，包括 3 名成功过渡到移植的患者，平均等待名单上 2.1 年。HeartMate 3 很少出现与设备相关的并发症，HeartMate 3 是先天性心脏病成人移植过渡或目的地策略的可行且可持续的选择。