<br>视黄酸和 TGF-β 协调器官特异性组织驻留程序,Immunity

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视黄酸和 TGF-β 协调器官特异性组织驻留程序
Immunity ( IF 25.5 ) Pub Date : 2024-10-14 , DOI: 10.1016/j.immuni.2024.09.015
Andreas Obers ₁ , Tobias Poch ₁ , Grace Rodrigues ₂ , Susan N Christo ₁ , Luke C Gandolfo ₃ , Raissa Fonseca ₁ , Ali Zaid ₁ , Joey En Yu Kuai ₁ , Hongjin Lai ₄ , Pirooz Zareie ₁ , Marina H Yakou ₅ , Lachlan Dryburgh ₁ , Thomas N Burn ₁ , James Dosser ₁ , Frank A Buquicchio ₆ , Caleb A Lareau ₆ , Calum Walsh ₁ , Louise Judd ₁ , Maria Rafailia Theodorou ₇ , Katharina Gutbrod ₈ , Peter Dörmann ₈ , Jenny Kingham ₉ , Tim Stinear ₁ , Axel Kallies ₁ , Jan Schroeder ₁ , Scott N Mueller ₁ , Simone L Park ₁₀ , Terence P Speed ₁₁ , Ansuman T Satpathy ₁₂ , Tri Giang Phan ₁₃ , Christoph Wilhelm ₇ , Colby Zaph ₂ , Maximilien Evrard ₁ , Laura K Mackay ₁

Affiliation

Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.
Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia; Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia.
Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Olivia Newton-John Cancer Research Institute, LaTrobe University School of Cancer Medicine, Heidelberg, VIC, Australia.
Department of Pathology, Stanford University, Stanford, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA.
Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.
Institute for Molecular Physiology and Biotechnology of Plants, University of Bonn, Bonn, Germany.
Australian BioResources Pty Ltd, Moss Vale, NSW, Australia; Animal Services, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia; Walter and Eliza Hall Institute for Medical Research, Parkville, VIC, Australia.
Department of Pathology, Stanford University, Stanford, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA; Parker Institute for Cancer Immunotherapy, Stanford University, Stanford, CA, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Precision Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia; St Vincent's Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia.

组织驻留记忆 T （TRM）细胞是组织免疫不可或缺的一部分，它们存在于不同的解剖部位，在那里它们粘附于一个共同的转录框架。这些细胞如何整合不同的局部线索以适应共同的 TRM 细胞命运仍然知之甚少。在这里，我们表明，虽然皮肤 TRM 细胞严格需要转化生长因子 β （TGF-β）才能进行组织驻留，但其他位置的细胞利用代谢物视黄酸（RA）来驱动另一种分化途径，指导肝脏中 TGF β非依赖性组织驻留程序，并与 TGF-β协同驱动小肠中的 TRM 细胞。我们发现 RA 是肠道 TRM 群体长期维持所必需的，部分原因是通过阻碍它们的逆行迁移。此外，增强的 RA 信号传导调节了 TRM 细胞表型和功能，这种现象在微生物多样性增加的小鼠中得到了反映。总之，我们的研究结果揭示了 RA 是指导组织中免疫监视的宿主-环境相互作用的基本组成部分。

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更新日期：2024-10-14

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