Findings from the Women's Health Initiative studies led to menopausal hormone therapy (MHT) guidelines generally recommending the initiation of MHT be limited to women within 10 years of their menopause or before the age of 60 years. This recommendation has led to women who experience troublesome menopausal symptoms and who have not commenced MHT within these limits often being denied this type of therapy. Similarly, the majority of women who might benefit from the protective effects of MHT against bone loss and fracture are not offered this treatment option if they do not fit with these criteria. Based on review of the evidence that led to the conditional initiation of MHT, and subsequent studies, we propose that the recommendations regarding the initiation of MHT need to change to be more inclusive of women outside these chronological limits.

中文翻译：

---

是时候重新审视开始更年期激素治疗的建议了吗？


女性健康倡议 （Women's Health Initiative） 的研究结果导致了更年期激素治疗 （MHT） 指南，该指南通常建议 MHT 的开始仅限于绝经后 10 年内或 60 岁之前的女性。该建议导致出现麻烦的更年期症状且未在这些范围内开始 MHT 的女性经常被拒绝接受此类治疗。同样，如果MHT对骨质流失和骨折的保护作用，大多数可能受益于MHT对骨质流失和骨折的保护作用的女性，如果她们不符合这些标准，则不会提供这种治疗选择。基于对导致有条件开始 MHT 的证据的回顾和后续研究，我们建议需要改变关于开始 MHT 的建议，以更加包容这些时间限制之外的女性。