The presence of Lewy body (LB) pathology in addition to Alzheimer disease (AD) pathology is associated with acceleration of AD-related disease progression, according to new research. In a study involving 795 participants with mild cognitive impairment or dementia, individuals with AD⁺LB⁺ biomarker profiles in their cerebrospinal fluid showed more rapid cognitive decline and greater cortical hypometabolism than those with AD⁺LB^–, AD^–LB⁺ or AD^–LB^– profiles. The findings suggest that the detection of LB pathology could have prognostic value in patients with AD.

中文翻译：

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路易体病理学加速 AD 进展

根据新的研究，除了阿尔茨海默病 （AD） 病理外，路易体 （LB） 病理的存在与 AD 相关疾病进展的加速有关。在一项涉及 795 名轻度认知障碍或痴呆参与者的研究中，脑脊液中具有 AD ⁺ LB ⁺ 生物标志物特征的个体比具有 AD ⁺ LB ^{– 、AD –} LB⁺ 或 AD ^– 特征的个体表现出更快的认知能力下降和更大的皮质代谢减退。研究结果表明，LB 病理的检测可能对 AD 患者具有预后价值。