Intracellular Redox Environment Determines Cancer-normal Cell Selectivity of Selenium Nanoclusters,Angewandte Chemie International Edition

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Intracellular Redox Environment Determines Cancer-normal Cell Selectivity of Selenium Nanoclusters
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-10-14 , DOI: 10.1002/anie.202416006
Zushuang Xiong ₁ , Lizhen He ₁ , Fen Pi ₁ , Yanzi Yu ₁ , Zhirong Xiao ₁ , Tianfeng Chen ₁

Affiliation

This study engineers Se−Se/Se−S bond to assemble selenium (Se) nanoclusters (SeClus) with intracellular redox environment-driven selective structure. This SeClus can be predominantly transformed to selenocysteine to facilitate selenoproteins synthesis in normal cells, while metabolize to cytotoxic SeO₃²⁻ based on the oxidative intracellular redox environment of cancer cells, thus exhibits high selectivity in cancer cells and normal cells.

中文翻译：

细胞内氧化还原环境决定了硒纳米团簇的癌症正常细胞选择性

本研究设计了 Se-Se/Se-S 键，以组装具有细胞内氧化还原环境驱动选择性结构的硒（Se）纳米簇（SeClus）。这种 SeClus 可以主要转化为硒代半胱氨酸以促进正常细胞中的硒蛋白合成，同时根据癌细胞的氧化细胞内氧化还原环境代谢为细胞毒性 SeO₃²⁻，因此在癌细胞和正常细胞中表现出高选择性。

更新日期：2024-10-14

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