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Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-10-06 , DOI: 10.1016/j.drup.2024.101158 Dajun Gao, Yanting Shen, Lingfan Xu, Yi Sun, Hailiang Hu, Bin Xu, Zhong Wang, Huan Xu
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-10-06 , DOI: 10.1016/j.drup.2024.101158 Dajun Gao, Yanting Shen, Lingfan Xu, Yi Sun, Hailiang Hu, Bin Xu, Zhong Wang, Huan Xu
Tumor fatty acid (FA) metabolic plasticity plays a pivotal role in resistance to therapy and poses limitations to anticancer strategies. In this study, our aim is to uncover the role of acetate metabolism in neurodifferentiation (NED)-mediated castration-resistant prostate cancer (CRPC).
中文翻译:
醋酸盐利用通过神经内分泌分化促进前列腺癌的激素治疗耐药性
肿瘤脂肪酸 (FA) 代谢可塑性在治疗耐药性中起关键作用,并限制了抗癌策略。在这项研究中,我们的目标是揭示乙酸盐代谢在神经分化 (NED) 介导的去势抵抗性前列腺癌 (CRPC) 中的作用。
更新日期:2024-10-06
中文翻译:
醋酸盐利用通过神经内分泌分化促进前列腺癌的激素治疗耐药性
肿瘤脂肪酸 (FA) 代谢可塑性在治疗耐药性中起关键作用,并限制了抗癌策略。在这项研究中,我们的目标是揭示乙酸盐代谢在神经分化 (NED) 介导的去势抵抗性前列腺癌 (CRPC) 中的作用。