Right ventricular outflow tract (RVOT) function is not systematically quantified by three-dimensional (3D) echocardiography. We tested the hypothesis that loss of RVOT function in pulmonary hypertension (PH) is related to disease severity independently of other echocardiographic parameters. In this observational study, patients with PH, disease controls, and a matched healthy control group underwent 3D echocardiography and RVOT analysis using ReVISION software. The study included 43 patients (38 with PH, 5 disease controls) and 43 healthy controls. Median 3D RVOT-ejection fraction (EF) was 30.4% in the patients and 44.2% in the healthy controls (p < 0.001). Patients with low 3D RVOT-EF (<30.4%) were more frequently categorized in higher-risk groups and had a higher incidence of clinical worsening than those with high 3D RVOT-EF. Even in patients with RV-EF ≥35%, those with low 3D RVOT-EF had worse outcomes. Segmental RVOT analysis identifies high-risk patients even with normal overall RV function.

中文翻译：

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肺动脉高压患者右心室流出功能丧失。


右心室流出道 （RVOT） 功能不能通过三维 （3D） 超声心动图系统地量化。我们检验了肺动脉高压 （PH） 中 RVOT 功能丧失与疾病严重程度相关的假设，独立于其他超声心动图参数。在这项观察性研究中，PH 患者、疾病对照患者和匹配的健康对照组使用 ReVISION 软件进行了 3D 超声心动图和 RVOT 分析。该研究包括 43 名患者 （38 名 PH，5 名疾病对照） 和 43 名健康对照者。患者的中位 3D RVOT 射血分数 （EF） 为 30.4%，健康对照为 44.2% （p < 0.001）。与高 3D RVOT-EF 患者 （<30.4%） 相比，低 3D RVOT-EF 患者更常被归类为高危组，临床恶化发生率更高。即使在 RV-EF ≥35% 的患者中，3D RVOT-EF 低的患者也预后较差。节段性 RVOT 分析可识别高危患者，即使整体 RV 功能正常。