PURPOSE To analyze the myopic maculopathy's progression pattern. DESIGN Retrospective, observational case series. METHODS 824 highly myopic eyes (axial length ≥26mm) of 430 patients examined at Puerta de Hierro-Majadahonda University Hospital (Madrid, Spain) with a minimum follow-up of 2 years. All patients underwent complete ophthalmologic examination, including multimodal imaging. Progression of myopic maculopathy was assessed according to ATN classification system at baseline and throughout the follow-up, as well as associated clinical features. RESULTS Progression of myopic maculopathy was described in 42% of eyes over a mean follow-up of 4.10±1.28 (range: 2.00 to 6.23) years. Compared to non-progressing eyes, myopic maculopathy progression correlated with worse best-corrected visual acuity (BCVA) at follow-up (p<0.05) and greater BCVA loss (p<0.01). There were no significant differences between groups in axial length, gender, and age (p>0.05). Eyes with posterior staphyloma (PS) and, particularly, those with macular PS showed significantly greater myopic maculopathy progression (p<0.01). The likelihood of myopic maculopathy's progression was 3.94 times higher (OR: 3.94±1.22, p<0.01) in eyes with PS compared to those without PS. Atrophic progression occurred in 21.9% of eyes, with diffuse to patchy atrophy being the most common pattern (54.17%). Tractional progression was observed in 22.8% of eyes, predominantly from non-traction to inner/outer foveoschisis (40%). Neovascular progression affected 11.4% of the eyes, most of them from no-neovascular component to macular lacquer cracks (40%). CONCLUSIONS The study highlights significant myopic maculopathy progression over the natural course of the disease, compromising the BCVA as macular complications progress. Myopic maculopathy progression was significantly associated with PS and, especially, with those with macular involvement.

中文翻译：

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近视性黄斑病变进展：对后葡萄球瘤和黄斑受累的见解。：简称：近视性黄斑病变进展。


目的 分析近视性黄斑病变的进展模式。设计 回顾性、观察性病例系列。方法 在 Puerta de Hierro-Majadahonda 大学医院（西班牙马德里）接受检查的 430 名患者的 824 只高度近视眼 （眼轴长度 ≥26mm） 进行检查，至少随访 2 年。所有患者均接受了完整的眼科检查，包括多模态成像。根据基线和整个随访期间的 ATN 分类系统评估近视性黄斑病变的进展，以及相关的临床特征。结果在平均随访 4.10±1.28 （范围：2.00 至 6.23） 年期间，42% 的眼睛描述了近视性黄斑病变的进展。与未进展的眼睛相比，近视性黄斑病变进展与随访时最佳矫正视力 （BCVA） 较差 （p<0.05） 和 BCVA 丢失较大 （p<0.01） 相关。组间眼轴长度、性别和年龄无显著差异 （p>0.05）。患有后葡萄肿 （PS） 的眼睛，尤其是患有黄斑 PS 的眼睛显示出显著更大的近视性黄斑病变进展 （p<0.01）。与无 PS 的眼睛相比，PS 眼近视黄斑病变进展的可能性高 3.94 倍 （OR： 3.94±1.22，p<0.01）。21.9% 的眼睛出现萎缩进展，弥漫性至斑片状萎缩是最常见的模式 （54.17%）。在 22.8% 的眼睛中观察到牵引进展，主要是从非牵引到内/外中央凹裂 （40%）。新生血管进展影响了 11.4% 的眼睛，其中大部分从无新生血管成分到黄斑漆裂 （40%）。 结论 该研究强调了在疾病的自然过程中显着的近视性黄斑病变进展，随着黄斑并发症的进展而损害 BCVA。近视性黄斑病变进展与 PS 显著相关，尤其是与黄斑受累的患者相关。