Ocular adnexal sebaceous carcinoma (OaSC) is an aggressive malignancy that often necessitates orbital exenteration. Its tumor composition and transcriptional profile remain largely unknown, which poses a significant barrier to medical advances. Here, we report the first in-depth transcriptomic analysis of OaSC at the single-cell resolution and discern mechanisms underlying cancer progression for the discovery of potential globe-sparing immunotherapies, targeted therapies, and biomarkers to guide clinical management.

中文翻译：

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眼附件皮脂腺癌的单细胞 RNA 分析揭示了复杂的肿瘤微环境并确定了新的生物标志物


眼附件皮脂腺癌 （OaSC） 是一种侵袭性恶性肿瘤，通常需要眼眶切除。其肿瘤组成和转录谱在很大程度上仍然未知，这对医学进步构成了重大障碍。在这里，我们报告了 OaSC 在单细胞分辨率下的首次深入转录组学分析，并辨别了癌症进展的潜在机制，以发现潜在的保全免疫疗法、靶向疗法和生物标志物来指导临床管理。