Biomaterials aim to address healthy issues and contribute to improve life quality for human beings. Currently available biomaterials have been challenged in performing theranostic objectives under real dynamic physiological conditions and at precise targeting sites. To address this concern, over the past few years in situ formulation of biomaterials has been developed to perform disease diagnosis and therapy in a precise manner involving different components. In this review, we introduced the concept of in situ-formed biomaterials and their design principles, specifically summarizing the progress of in situ-formed biomaterials based on stimulus-responsive self-assembly of peptides in living systems. We highlighted the recent examples of in situ assembling systems of peptides with applications ranging from cancer therapy, anti-inflammation and anti-bacteria, as well as tissue engineering and regeneration. The challenges met by in situ biomaterials and the prospects of in situ peptide assembly towards biomedicines are also discussed, which hopefully elucidates the great potential of in situ-formed biomaterials for future healthcare.

中文翻译：

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用于疾病治疗的生物材料的原位配方：肽组装策略的最新进展


生物材料旨在解决健康问题，并为提高人类的生活质量做出贡献。目前可用的生物材料在真实动态生理条件和精确靶向位点执行治疗诊断目标方面受到了挑战。为了解决这一问题，在过去几年中，已经开发了生物材料的原位配方，以涉及不同成分的精确方式进行疾病诊断和治疗。在这篇综述中，我们介绍了原位形成的生物材料的概念及其设计原则，具体总结了基于生命系统中肽刺激响应自组装的原位形成生物材料的研究进展。我们重点介绍了肽原位组装系统的最新示例，其应用范围包括癌症治疗、抗炎和抗菌，以及组织工程和再生。还讨论了原位生物材料面临的挑战以及原位肽组装对生物医学的前景，希望能阐明原位形成的生物材料在未来医疗保健中的巨大潜力。