Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic translation. Several regulators participate in the modulation of mitochondrial translation. Mitochondrial translation is coordinated with cytoplasmic translation through stress responses. Importantly, the inhibition of mitochondrial translation leads to the inhibition of cytoplasmic translation and metabolic disruption. Therefore, defects in mitochondrial translation are closely related to the functions of hematopoietic cells and various immune cells. Finally, the inhibition of mitochondrial translation is a potential therapeutic target for treating multiple hematologic malignancies. Collectively, more in-depth insights into mitochondrial translation not only facilitate our understanding of its functions in hematopoiesis, but also provide a basis for the discovery of new treatments for hematological malignancies and the modulation of immune cell function.

中文翻译：

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揭示线粒体翻译在正常和恶性造血中的作用和机制


由于空间和基因组独立性，线粒体具有不同于细胞质翻译的翻译机制。几种调节因子参与线粒体翻译的调节。线粒体翻译通过应激反应与细胞质翻译相协调。重要的是，线粒体翻译的抑制导致细胞质翻译和代谢破坏的抑制。因此，线粒体翻译缺陷与造血细胞和各种免疫细胞的功能密切相关。最后，抑制线粒体翻译是治疗多发性血液系统恶性肿瘤的潜在治疗靶点。总的来说，对线粒体翻译的更深入见解不仅有助于我们理解其在造血中的功能，而且为发现血液系统恶性肿瘤的新治疗方法和免疫细胞功能的调节提供了基础。