BackgroundMeningioma risk factors include older age, female sex, and being Black/African American. Limited data explore how meningioma risk in individuals who are Black varies across the lifespan, interacts with sex, and differs by tumor grade.MethodsThe Central Brain Tumor Registry of the United States is a population-based registry covering the entire US population. Meningioma diagnoses from 2004 to 2019 were used to calculate incidence rate ratios for non-Hispanic Black individuals compared with non-Hispanic White individuals across 10-year age intervals and stratified by sex and World Health Organization tumor grade in this retrospective study.ResultsA total of 53 890 non-Hispanic Black individuals and 322 373 non-Hispanic White individuals with an intracranial meningioma diagnosis were included in analyses. Beginning in young adulthood, the non-Hispanic Black to non-Hispanic White incidence rate ratio was elevated for grade 1 and grades 2-3 tumors. The incidence rate ratio peaked in the seventh decade of life regardless of grade and was higher for grades 2-3 tumors (incidence rate ratio = 1.57, 95% confidence interval [CI] = 1.46 to 1.69) than grade 1 tumors (incidence rate ratio = 1.27, 95% CI = 1.25 to 1.30) in this age group. The non-Hispanic Black to non-Hispanic White incidence rate ratio was elevated in women (incidence rate ratio = 1.17, 95% CI = 1.16 to 1.18) and was further elevated in men (incidence rate ratio = 1.28, 95% CI = 1.26 to 1.30), revealing synergistic interaction between non-Hispanic Black race and ethnicity and male sex (Pinteraction = .001).ConclusionsRelative to non-Hispanic White individuals, non-Hispanic Black individuals are at elevated risk of meningioma from young adulthood through old age. Non-Hispanic Black race and ethnicity conferred greater risk of meningioma among men than women and greater risk of grades 2-3 tumors. Population-level differences in meningioma incidence and tumor behavior suggest potential disparities in the geographic, socioeconomic, and racial distribution of meningioma risk factors within the United States.

中文翻译：

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非西班牙裔黑人个体的分级分层脑膜瘤风险以及与男性的相互作用


背景脑膜瘤危险因素包括高龄、女性和黑人/非裔美国人。有限的数据探讨了黑人个体的脑膜瘤风险如何在一生中变化，与性别相互作用，并因肿瘤分级而异。方法美国中央脑肿瘤登记处是一个基于人群的登记处，涵盖整个美国人群。在这项回顾性研究中，2004 年至 2019 年的脑膜瘤诊断用于计算非西班牙裔黑人与非西班牙裔白人在 10 岁年龄间隔内的发病率比，并按性别和世界卫生组织肿瘤分级分层。结果共纳入 53 890 名诊断为颅内脑膜瘤的非西班牙裔黑人和 322 373 名非西班牙裔白人。从成年早期开始，1 级和 2-3 级肿瘤的非西班牙裔黑人与非西班牙裔白人的发病率比值升高。无论级别如何，发病率比在生命的第七个十年达到峰值，并且 2-3 级肿瘤 （发病率比 = 1.57,95% 置信区间 [CI] = 1.46 至 1.69） 高于 1 级肿瘤 （发病率比 = 1.27,95% CI = 1.25 至 1.30） 在该年龄组中。非西班牙裔黑人与非西班牙裔白人的发病率比在女性中升高 （发病率比 = 1.17,95% CI = 1.16 至 1.18），在男性中进一步升高 （发病率比 = 1.28,95% CI = 1.26 至 1.30），揭示了非西班牙裔黑人种族和族裔与男性之间的协同相互作用 （Pinteraction = .001）。结论相对于非西班牙裔白人个体，非西班牙裔黑人个体从青年到老年患脑膜瘤的风险升高。 非西班牙裔黑人种族和族裔男性患脑膜瘤的风险高于女性，患 2-3 级肿瘤的风险更大。脑膜瘤发病率和肿瘤行为的人群水平差异表明，美国境内脑膜瘤危险因素的地理、社会经济和种族分布存在潜在差异。