Background Meningioma risk factors include older age, female sex, and African-American race. Limited data explore how meningioma risk in African-Americans varies across the lifespan, interacts with sex, and differs by tumor grade. Methods The Central Brain Tumor Registry of the United States (CBTRUS) is a population-based registry covering the entire U.S. population. Meningioma diagnoses from 2004-2019 were used to calculate incidence rate ratios (IRRs) for non-Hispanic Black individuals (NHB) compared to non-Hispanic white individuals (NHW) across 10-year age intervals, and stratified by sex and by WHO tumor grade in this retrospective study. Results 53,890 NHB individuals and 322,373 NHW individuals with an intracranial meningioma diagnosis were included in analyses. Beginning in young adulthood, the NHB-to-NHW IRR was elevated for both grade 1 and grade 2/3 tumors. The IRR peaked in the seventh decade of life regardless of grade, and was higher for grade 2/3 tumors (IRR = 1.57; 95% CI: 1.46-1.69) than grade 1 tumors (IRR = 1.27; 95% CI: 1.25-1.30) in this age group. The NHB-to-NHW IRR was elevated in females (IRR = 1.17; 95% CI: 1.16-1.18) and was further elevated in males (IRR = 1.28; 95% CI: 1.26-1.30), revealing synergistic interaction between NHB race/ethnicity and male sex (PInteraction=0.001). Conclusions Relative to NHW individuals, NHB individuals are at elevated risk of meningioma from young adulthood through old age. NHB race/ethnicity conferred greater risk of meningioma among men than women, and greater risk of grade 2/3 tumors. Population-level differences in meningioma incidence and tumor behavior suggest potential disparities in the geographic, socioeconomic, and racial distribution of meningioma risk factors within the U.S.

中文翻译：

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非西班牙裔黑人个体的分级分层脑膜瘤风险以及与男性的互动


背景 脑膜瘤危险因素包括高龄、女性和非裔美国人种。有限的数据探讨了非裔美国人脑膜瘤风险在一生中如何变化，与性别相互作用，以及因肿瘤分级而异。方法 美国中央脑肿瘤登记处 （CBTRUS） 是一个基于人群的登记处，涵盖整个美国人口。2004-2019 年的脑膜瘤诊断用于计算非西班牙裔黑人 （NHB） 与非西班牙裔白人 （NHW） 在 10 年年龄间隔内的发病率比 （IRR），并按性别和 WHO 肿瘤分级分层在本回顾性研究中。结果 分析纳入 53,890 例 NHB 个体和 322,373 例颅内脑膜瘤诊断的 NHW 个体。从成年早期开始，1 级和 2/3 级肿瘤的 NHB 到 NHW IRR 均升高。无论级别如何，IRR 在生命的第七个十年达到峰值，并且 2/3 级肿瘤的 IRR （IRR = 1.57;95% CI： 1.46-1.69） 高于 1 级肿瘤 （IRR = 1.27;95% CI： 1.25-1.30）。NHB 到 NHW 的 IRR 在女性中升高 （IRR = 1.17;95% CI： 1.16-1.18），在男性中进一步升高 （IRR = 1.28;95% CI： 1.26-1.30），揭示了 NHB 种族/族裔与男性之间的协同作用 （PInteraction=0.001）。结论 相对于 NHW 个体，NHB 个体从青年到老年患脑膜瘤的风险升高。NHB 种族/族裔赋予男性比女性更大的脑膜瘤风险，以及更大的 2/3 级肿瘤风险。脑膜瘤发病率和肿瘤行为的人群水平差异表明美国脑膜瘤危险因素的地理、社会经济和种族分布存在潜在差异。