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Prevalence, Features and Risk Factors of Macular Retinoschisis in High Myopic Population: the Beijing Eye Study 2011: Macular Retinoschisis in High Myopic Population.
American Journal of Ophthalmology ( IF 4.1 ) Pub Date : 2024-10-08 , DOI: 10.1016/j.ajo.2024.10.003 Zhe Pan,Yu Huang,Zihan Li,Wenqing Liu,Ziyao Wang,Chun Zhang,Jost B Jonas,Ya Xing Wang
American Journal of Ophthalmology ( IF 4.1 ) Pub Date : 2024-10-08 , DOI: 10.1016/j.ajo.2024.10.003 Zhe Pan,Yu Huang,Zihan Li,Wenqing Liu,Ziyao Wang,Chun Zhang,Jost B Jonas,Ya Xing Wang
PURPOSE
To investigate the prevalence, features and risk factors of macular retinoschisis (MRS) in highly myopic eyes and their morphological features in Chinese population.
DESIGN
Population-based, cross-sectional study.
PARTICIPANTS
From Beijing Eye Study 2011, a total of 213 highly myopic eyes from 129 participants were included.
METHODS
All participants underwent Spectral-domain optical coherence tomography with a macula cube scan of 30° × 30°centered in the fovea.
MAIN OUTCOME MEASURES
High myopia was defined as a refractive error ≤-6 diopters or an axial length ≥ 26.0 mm. MRS presence and its subtypes were assessed based on location and affected retinal layers were evaluated. Prevalence, features and associated factors of MRS and its subtypes in highly myopic population were assessed.
RESULTS
Out of 213 highly myopic eyes (129 participants), MRS was observed in 48 eyes, with a prevalence of 22.5% (95%CI: 16.9, 28.6%) per eye, or 36 participants with 27.9% (95% CI: 20.5, 35.7%) per subject. In addition to well-documented factors like older age and higher myopia, the prevalence of MRS was found to be related with a higher intraocular pressure (P=0.013, OR: 1.25; 95%CI: 1.05, 1.48), a thinner subfoveal choroidal thickness (P=0.006 OR: 0.86; 95%CI: 0.77, 0.96), a wider Gamma zone (P=0.003, OR: 1.99; 95%CI: 1.05, 3.11), the presence of glaucoma (P=0.010, OR: 3.37; 95%CI: 1.34, 8.48) and the presence of epiretinal membrane (P=0.023, OR: 3.13; 95%CI: 1.17, 8.36), after multivariate analysis. Eyes with advanced high myopia (P=0.021) and wider gamma zone (P=0.005) were more likely to develop foveal MRS. Eyes with glaucoma tended to have a higher prevalence of outer retinal MRS compared to inner retinal MRS (60.9% versus 36.0%), though the difference was not statistically significant (P=0.06). MRS located in the foveal region or affecting the outer retina was related with a significant worse best corrected visual acuity (BCVA), as compared to MRS that was perifoveally located or affected other regions (P<0.05).
CONCLUSIONS
The prevalence of MRS was 27.9% among the elderly highly myopic population. MRS occurring in the foveal region or involving the outer retina demands increased vigilance due to its significant impact on BCVA. The findings contribute to a deeper understanding of MRS, offering insights into its mechanisms and vision prognosis.
更新日期：2024-10-08
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