Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.

中文翻译：

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培养瓶中的新底盘：自然弧菌生物技术研究的进展


生物技术是建立在少数特征明确、设计精良的生物体的基础上的。近年来，生物工程工具箱中出现了一个突破性的物种，它作为新进入者而受到关注：纳特里根弧菌。这篇综述涵盖了使 V. natriegens 成为生物技术平台的最新研究工作，使用大型语言模型 （LLM） 和知识图谱来加快文献调查过程。科学家们在与 V. natriegens 的基本代谢特征、合成生物学工具的开发和表征、系统生物学分析和代谢建模、生物生产和代谢工程以及微生物生态学有关的研究方面取得了进展。这些子类别中的每一个都与生物工程应用中的 V. natriegens 的未来相关。在这篇综述中，我们涵盖了这些最近的进展，并提供了它们可能对该领域产生影响的背景，强调了使用这种生物体的优点和缺点。从最近的生物工程研究来看，V. natriegens 似乎正处于成为未来生物技术平台细菌的边缘。