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Fever affects T cell fate
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2024-10-11 , DOI: 10.1038/s41577-024-01101-w
Lucy Bird

Febrile temperatures disrupt metabolism and induce DNA damage disproportionately in T helper 1 cell subsets. Cells that survive apoptosis and adapt by increasing their mitochondrial mass and DNA damage responses gain enhanced effector functions.

中文翻译:


发热影响 T 细胞的命运



发热会破坏新陈代谢,并在辅助性 T 细胞 1 亚群中不成比例地诱导 DNA 损伤。在细胞凋亡中存活并通过增加线粒体质量和 DNA 损伤反应来适应的细胞获得了增强的效应功能。
更新日期:2024-10-11
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