ObjectiveTo determine the association between unilateral oophorectomy (UO) and age at natural menopause.DesignSecondary analysis of survey data from Alberta's Tomorrow Project (2000–2022).SettingProspective cohort study in Alberta, Canada.Population23 630 women; 548 experienced UO and 23 082 did not experience UO.MethodsFlexible parametric survival analysis was used to analyse age at natural menopause, and logistic regression was used to analyse early menopause and premature ovarian insufficiency by UO status, controlling for birth year, parity, age at menarche, past infertility, hormonal contraceptive use and smoking.Main Outcome MeasuresAge at natural menopause occurred by a final menstrual period without medical cause and sub‐classified as early menopause (< 45 years) and premature ovarian insufficiency (< 40 years).ResultsCompared to no UO, any UO was associated with elevated risk of earlier age at natural menopause, which was strongest in early midlife (adjusted HR at age 40 1.71, 95% CI 1.31–2.19) and diminished over time. Compared to age 55 years at UO, risks of earlier age at natural menopause were largest and uniform in magnitude when UO occurred between approximately ages 20–40 years (adjusted HR for UO at age 30 2.32, 1.46–3.54) and then diminished as age at UO approached the average age at natural menopause. Any UO was associated with higher odds of early menopause (adjusted OR 1.90, 1.30–2.79) and premature ovarian insufficiency (adjusted OR 3.75, 1.72–8.16).ConclusionsUnilateral oophorectomy is associated with earlier age at natural menopause, particularly when performed before 40 years of age.

中文翻译：

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单侧卵巢切除术和自然绝经年龄：一项基于社区的纵向队列研究


目的确定单侧卵巢切除术 （UO） 与自然绝经年龄的相关性。设计对阿尔伯塔省 Tomorrow Project （2000-2022） 的调查数据进行二次分析。地点加拿大阿尔伯塔省的前瞻性队列研究.人口23 630 名女性;548 名有经验的 UO 和 23 082 名没有经历过 UO。方法采用灵活的参数生存分析分析自然绝经年龄，采用 logistic 回归按 UO 状态分析早期绝经和卵巢早衰，控制出生年份、胎次、初潮年龄、既往不孕症、激素避孕药具使用和吸烟。主要结局指标自然绝经年龄发生在无医学原因的末次月经期，细分为更年期早 （< 45 岁） 和卵巢早衰 （< 40 岁）。结果与无 UO 相比，任何 UO 都与自然绝经时较早年龄的风险增加相关，这种风险在中年早期最强（40 岁校正 HR 为 1.71,95% CI 1.31-2.19），并随着时间的推移而降低。与 UO 的 55 岁相比，当 UO 发生在大约 20-40 岁之间时，自然绝经年龄较早的风险最大且幅度一致（30 岁时 UO 的调整 HR 为 2.32、1.46-3.54），然后随着 UO 年龄接近自然绝经的平均年龄而降低。任何 UO 都与早期绝经 （校正 OR 1.90， 1.30-2.79） 和卵巢早衰 （校正 OR 3.75， 1.72-8.16） 的较高几率相关。结论单侧卵巢切除术与自然绝经年龄较早相关，尤其是在 40 岁之前进行时。