ObjectivesThis controlled preclinical study analyzed the effect of implant surface characteristics on osseointegration and crestal bone formation in a grafted dehiscence defect minipig model.Material and MethodsA standardized 3 mm × 3 mm acute‐type buccal dehiscence minipig model grafted with deproteinized bovine bone mineral and covered with a porcine collagen membrane after 2 and 8 weeks of healing was utilized. Crestal bone formation was analyzed histologically and histomorphometrically to compare three implant groups: (1) a novel, commercially available, gradient anodized (NGA) implant, to two custom‐made geometric replicas of implant “1,” (2) a superhydrophilic micro‐rough large‐grit sandblasted and acid‐etched surface, and (3) a relatively hydrophobic micro‐rough large‐grit sandblasted and acid‐etched surface.ResultsAt 2 and 8 weeks, there was no difference between the amount and height of newly formed bone (NBH, new bone height; BATA, bone area to total area) for any of the groups (p > 0.05). First bone‐to‐implant contact (fBIC) and vertical bone creep (VBC) at 2 and 8 weeks were significantly increased for Groups 2 and 3 compared to Group 1 (p < 0.05). At 8 weeks, osseointegration in the dehiscence (dehiscence bone‐implant‐contact; dBIC) was significantly higher for Groups 2 and 3 compared to Group 1 (p < 0.05).ConclusionsThe amount of newly formed bone (BATA) and NBH was not influenced by surface type. However, moderately rough surfaces demonstrated significantly superior levels of osseointegration (dBIC) and coronal bone apposition (fBIC) in the dehiscence defect compared to the NGA surface at 2 and 8 weeks.Trial RegistrationFor this type of study, clinical trial registration is not required. This study was conducted at the Biomedical Department of Lund University (Lund, Sweden) and approved by the local Ethics Committee of the University (M‐192‐14)

中文翻译：

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引导骨再生急性裂开型缺损中阳极氧化与喷砂种植体表面的骨结合：一种体内实验性下颌微型猪模型


目的本临床对照研究分析了种植体表面特征对移植裂开缺损微型猪模型中骨结合和牙槽嵴骨形成的影响。材料和方法使用标准化的 3 mm × 3 mm 急性型颊裂开微型猪模型，用脱蛋白牛骨矿物质移植，并在愈合 2 周和 8 周后覆盖猪胶原膜。通过组织学和组织形态学分析牙槽嵴骨形成，以比较三个种植体组：（1） 一种新型的市售梯度阳极氧化 （NGA） 种植体与种植体“1”的两个定制几何复制品，（2） 超亲水性微粗糙大砂喷砂和酸蚀表面，以及 （3） 相对疏水性的微粗糙大砂喷砂和酸蚀表面。结果在 2 周和 8 周时，新形成的骨的数量和高度没有差异 （NBH，新骨高度;BATA，骨面积与总面积之比）（p > 0.05）。与第 1 组相比，第 2 组和第 3 组在 2 周和 8 周时的首次骨与种植体接触 （fBIC） 和垂直骨蠕变 （VBC） 显著增加 （p < 0.05）。8 周时，与第 1 组相比，第 2 组和第 3 组裂开 （裂开骨-种植体-接触;dBIC） 的骨整合显着升高 （p < 0.05）。结论新形成骨量 （BATA） 和 NBH 不受表面类型的影响。然而，在 2 周和 8 周时，与 NGA 表面相比，中度粗糙表面在裂开缺损中表现出明显优于 NGA 表面的骨整合 （dBIC） 和冠状骨并置 （fBIC） 水平。试验注册对于此类研究，不需要临床试验注册。这项研究是在隆德大学（瑞典隆德）生物医学系进行的，并得到了当地大学伦理委员会 （M-192-14） 的批准