We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, transcriptomics and mass spectrometry-based immunopeptidomics. NeoDisc accurately identifies and prioritizes tumor-specific antigens and designs personalized cancer vaccines. The pipeline reveals tumor heterogeneity and emphasizes defects in antigen presentation that might affect the success of cancer immunotherapy.

中文翻译：

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抗原发现管道整合了多组学数据并为免疫治疗提供信息


我们开发了 NeoDisc，这是一种计算抗原发现管道，集成了多组学数据，包括基因组学、转录组学和基于质谱的免疫肽组学。NeoDisc 准确识别肿瘤特异性抗原并确定其优先级，并设计个性化的癌症疫苗。该管道揭示了肿瘤异质性，并强调了可能影响癌症免疫治疗成功的抗原呈递缺陷。