Recent advances in artificial transmembrane transporters that may address the limitations of natural ion channels include a photoswitchable Cl⁻ anion pump developed by Aprahamian et al., reported in Science,¹ utilizing hydrazone units for active transport against the concentration gradient. This molecular transporter leverages light-induced isomerization to control anion grabbing and releasing, showing significant potential for drug discovery and molecular machinery.

中文翻译：

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一种光驱动氯离子阴离子转运蛋白


可能解决天然离子通道局限性的人工跨膜转运蛋白的最新进展包括 Aprahamian 等人开发的可光开关 Cl⁻ 阴离子泵，该泵在《科学》杂志上报道，¹ 利用腙单元对浓度梯度进行主动运输。这种分子转运蛋白利用光诱导异构化来控制阴离子的抓取和释放，在药物发现和分子机制方面显示出巨大的潜力。