The production of tailored biological drugs by genetic engineering represents a significant challenge in the field of natural product chemistry. In this issue of Chem, Bode and co-workers have successfully developed a biosynthetic production platform for novel syrbactin-class proteasome inhibitors by assembling an NRPS/PKS hybrid from four different natural megasynthetases.

中文翻译：

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通过合理的途径工程对蛋白酶体抑制剂进行微调


通过基因工程生产定制生物药物是天然产物化学领域的重大挑战。在本期 Chem 中，Bode 及其同事通过组装四种不同的天然巨合成酶的 NRPS/PKS 杂交体，成功开发了一种用于新型 syrbactin 类蛋白酶体抑制剂的生物合成生产平台。