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Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Molecular Neurodegeneration ( IF 14.9 ) Pub Date : 2024-10-10 , DOI: 10.1186/s13024-024-00764-2
Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia

Molecular Neurodegeneration (2024) 19:18

https://doi.org/10.1186/s13024-023-00700-w

The original article erroneously presents incorrect graph labels in the caption of Fig. 4. The corrected Fig. 4 caption alongside its respective figure can be viewed ahead in this Correction article.

Fig. 4
figure 4

GV-971 modifies cytokine and chemokine levels in peripheral blood and cortical tissues. (a) Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 male mice treated with 160mg/kg GV-971 or vehicle from the University of Chicago (n = 10–11). (b) Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 female mice treated with 160mg/kg GV-971 or vehicle (n = 8–10). (c) Quantification of cytokine and chemokine concentrations in the serum of 5XFAD male mice treated with 100mg/kg GV-971 or vehicle from Washington University in St. Louis (n = 12–13). (d) Quantification of cytokine and chemokine concentrations in the serum of 5XFAD female mice treated with 100mg/kg GV-971 or vehicle (n = 9–12). (e) Quantification of cytokine and chemokine concentrations in the cortical tissue of 5XFAD male mice treated with 100mg/kg GV-971 or vehicle (n = 12–13). Data presented as SEM. Significance determined using unpaired t-test. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001

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Author notes

  1. Megan E. Bosch and Hemraj B. Dodiya contributed equally to this work.

  2. Julia Michalkiewicz, Choonghee Lee and Shabana M. Shaik contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, St. Louis, USA

    Megan E. Bosch, Choonghee Lee, Aishwarya Nambiar, Samira Parhizkar & David M. Holtzman

  2. Department of Neurobiology, University of Chicago, Chicago, USA

    Hemraj B. Dodiya, Julia Michalkiewicz, Shabana M. Shaik, Ian Q. Weigle, Jack Osborn, Xiaoqiong Zhang & Sangram S. Sisodia

  3. Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Can Zhang, Prasenjit Mondal, Ashley Gomm & Rudolph E. Tanzi

  4. Center for Genetic Medicine, Northwestern University, Chicago, USA

    Priyam Patel & Matthew John Schipma

  5. Genome Technology Access Center, Washington University in St. Louis, St. Louis, USA

    Marie L. Laury

  6. Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Dania Mallah & Oleg Butovsky

  7. Department Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago, Chicago, USA

    Eugene B. Chang

  8. Department of Pediatrics and Scripps Institution of Oceanography, UCSD, San Diego, USA

    Jack A. Gilbert

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Corresponding authors

Correspondence to David M. Holtzman or Sangram S. Sisodia.

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Bosch, M.E., Dodiya, H.B., Michalkiewicz, J. et al. Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegeneration 19, 70 (2024). https://doi.org/10.1186/s13024-024-00764-2

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中文翻译：

更正：寡甘露酸钠改变肠道微生物群，以性别特异性方式减少脑淀粉样变性和反应性小胶质细胞


分子神经退行性变 （2024） 19：18

https://doi.org/10.1186/s13024-023-00700-w


原始文章在图 4 的标题中错误地显示了不正确的图形标签。更正后的图 4 标题及其各自的图表可以在这篇更正文章中提前查看。

 图 4
figure 4


GV-971 改变外周血和皮质组织中的细胞因子和趋化因子水平。（a） 用 160mg/kg GV-971 或芝加哥大学载体处理的 APPPS1-21 雄性小鼠血清中细胞因子和趋化因子浓度的定量 （n = 10-11）。（b） 用 160mg/kg GV-971 或载体 （n = 8-10） 处理的 APPPS1-21 雌性小鼠血清中细胞因子和趋化因子浓度的定量。（c） 用 100mg/kg GV-971 或圣路易斯华盛顿大学的载体处理的 5XFAD 雄性小鼠血清中细胞因子和趋化因子浓度的定量 （n = 12-13）。（d） 用 100mg/kg GV-971 或载体 （n = 9-12） 处理的 5XFAD 雌性小鼠血清中细胞因子和趋化因子浓度的定量。（e） 用 100mg/kg GV-971 或载体 （n = 12-13） 处理的 5XFAD 雄性小鼠皮质组织中细胞因子和趋化因子浓度的定量。数据以 SEM 表示。使用未配对的 t 检验确定显着性。*， P<0.05;**， P<0.01;， P<0.001;，P<0.0001

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 作者注释


  1. Megan E. Bosch 和 Hemraj B. Dodiya 对这项工作做出了同样的贡献。


  2. Julia Michalkiewicz、Choonghee Lee 和 Shabana M. Shaik 对这项工作做出了同样的贡献。

 作者和单位


  1. 美国圣路易斯华盛顿大学奈特阿尔茨海默病研究中心 Hope 神经疾病中心神经病学系


    梅根· E·博世，李钟熙，艾西瓦娅·南比亚，萨米拉·帕希兹卡和大卫· M·霍尔茨曼


  2. 芝加哥大学神经生物学系，美国芝加哥


    Hemraj B. Dodiya， Julia Michalkiewicz， Shabana M. Shaik， Ian Q. Weigle， Jack Osborn， Xiaoqiong Zhang & Sangram S. Sisodia


  3. 美国马萨诸塞州波士顿哈佛医学院马萨诸塞州总医院神经病学系 McCance 脑健康中心神经退行性疾病研究所遗传学和衰老研究部


    张灿， 普拉森吉特·蒙达尔， 阿什利·戈姆 & 鲁道夫· E. 坦齐


  4. 美国芝加哥西北大学遗传医学中心

    Priyam Patel & Matthew John Schipma


  5. 美国圣路易斯华盛顿大学基因组技术访问中心

     玛丽·劳里


  6. 美国马萨诸塞州波士顿哈佛医学院布莱根妇女医院神经病学系安·羅姆尼神经病中心


    达尼娅·马拉 & 奥列格·布托夫斯基


  7. 美国芝加哥大学胃肠病学、肝病学和营养学系医学系

     张友仁


  8. 美国圣地亚哥加州大学圣地亚哥分校儿科和斯克里普斯海洋研究所

     杰克·吉尔伯特

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与 David M. Holtzman 或 Sangram S. Sisodia 的通信。

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施普林格·自然 （Springer Nature） 对已发布的地图和机构隶属关系中的管辖权主张保持中立。


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Bosch， ME， Dodiya， HB， Michalkiewicz， J. 等人。更正：寡甘露酸钠改变肠道微生物群，以性别特异性方式减少脑淀粉样变性和反应性小胶质细胞。分子神经变性 19， 70 （2024）。https://doi.org/10.1186/s13024-024-00764-2

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