This review examines the crucial roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological relevance of these changes. We highlight primary pathologies of the ChP, as well as their significance in neurologic disorders, including stroke, hydrocephalus, infectious diseases, and neurodegeneration. Synthesizing recent research, this review positions the ChP as a critical player in CNS homeostasis and pathology, advocating for enhanced focus on its mechanisms to unlock new diagnostic and treatment strategies and ultimately improve patient outcomes in CNS diseases. Whether acting as a principal driver of disease, a gateway for pathogens into the CNS, or an orchestrator of neuroimmune processes, the ChP holds tremendous promise as a therapeutic target to attenuate a multitude of CNS conditions.

中文翻译：

---

脉络丛病理生理学


本综述研究了脉络丛 （ChP） 在中枢神经系统 （CNS） 病理学中的关键作用，强调了其参与疾病机制和治疗潜力。在病例报告和描述性工作中，已报道了各种疾病中人类 ChP 的结构变化，但研究尚未确定这些变化的生理相关性。我们重点介绍了 ChP 的主要病理，以及它们在神经系统疾病（包括中风、脑积水、传染病和神经退行性变）中的重要性。本综述综合了最近的研究，将 ChP 定位为 CNS 稳态和病理学的关键参与者，倡导加强对其机制的关注，以解锁新的诊断和治疗策略，并最终改善 CNS 疾病患者的预后。无论是作为疾病的主要驱动因素、病原体进入 CNS 的门户，还是神经免疫过程的协调器，ChP 作为减轻多种 CNS 疾病的治疗靶点都具有巨大的前景。