Over the past three decades, chiral phase-transfer catalysts (PTCs) have emerged as highly successful organocatalysts in a diverse range of asymmetric reactions. A substantial number of chiral PTCs have now already been discovered and utilized in dependable routes to enantioenriched products. These extend beyond the classical cationic PTCs with the emergence of anionic phase-transfer catalysis and hydrogen-bonding phase-transfer catalysis providing new asymmetric synthetic approaches. Nevertheless, the application level of chiral PTCs in both academic and industrial processes is below our expectation. This Review highlights the notable advances in chiral PTCs, including challenges, limitations and efforts to overcome them. Following this, the potential for sustainable chiral PTCs is described with a focus on using photocatalysed, flow and electrochemical synthesis.

在过去的三十年里，手性相转移催化剂 （PTC） 已成为各种不对称反应中非常成功的有机催化剂。现在已经发现了大量手性 PTC 并用于可靠的对映体富集产品路线。随着阴离子相转移催化和氢键相转移催化的出现，这些方法超越了经典的阳离子 PTC，提供了新的不对称合成方法。尽管如此，手性 PTC 在学术和工业过程中的应用水平都低于我们的预期。本综述重点介绍了手性 PTC 的显著进展，包括挑战、局限性和克服这些挑战的努力。在此之后，描述了可持续手性 PTC 的潜力，重点是使用光催化、流动和电化学合成。