Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert damaging effects due to oxidative stress on heart and blood vessels. Although NOX-dependent ROS production is implicated in pathogenesis, the relationship between HDACs and NOXs in CVDs remains to be elucidated. Here, we present an overview of the regulatory effects and interconnected signaling pathways of HDACs and NOXs in CVDs. Improved insights into these relationships will facilitate the discovery of novel therapeutic agents that target HDACs, oxidase stress pathways, and the interactions between these systems which may be highly effective in the prevention and treatment of cardiovascular disorders.

中文翻译：

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组蛋白脱乙酰酶和 NADPH 氧化酶对心血管疾病的调节


组蛋白脱乙酰酶 （HDAC） 在心血管疾病 （CVD） 中起着关键作用。此外，NADPH 氧化酶 （NOX） 产生的活性氧 （ROS） 由于氧化应激而对心脏和血管产生破坏作用。尽管 NOX 依赖性 ROS 的产生与发病机制有关，但 HDAC 和 CVD 中 NOX 之间的关系仍有待阐明。在这里，我们概述了 HDAC 和 NOX 在 CVD 中的调节作用和相互关联的信号通路。对这些关系的更深入的了解将有助于发现靶向 HDACs、氧化酶应激途径以及这些系统之间的相互作用的新型治疗剂，这可能在预防和治疗心血管疾病方面非常有效。