Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, and sex and gender experts reviewed current literature on the effect of sex and gender dimensions on IBD outcomes. The team also investigated the role that stakeholders have in advancing sex-based and gender-based IBD knowledge, as comprehensive studies are scarce. Acknowledging and integrating sex and gender into the organisation and content of research (eg, study design, participant recruitment, data analysis, data interpretation, data dissemination, and impact evaluation) could enhance the validity, relevance, and applicability of research. Such gendered innovation has potential for advancing personalised medicine and improving the quality of life for people with IBD.

中文翻译：

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炎症性肠病结局和研究中的性别和性别


广泛的患者异质性是炎症性肠病 （IBD） 管理中的一个挑战。性和性别，以及性和性别与其他社会身份的相互作用，称为交叉性，导致了这种异质性，并可能影响 IBD 结果。一个由临床医生、研究人员、患者以及性和性别专家组成的跨学科团队回顾了当前关于性别和性别维度对 IBD 结果影响的文献。该团队还调查了利益相关者在推进基于性别和基于性别的 IBD 知识方面的作用，因为缺乏全面的研究。承认性和性别并将其纳入研究的组织和内容（例如，研究设计、受试者招募、数据分析、数据解释、数据传播和影响评估）可以提高研究的有效性、相关性和适用性。这种性别创新有可能推进个性化医疗和改善 IBD 患者的生活质量。