In this manuscript, we report a natural photoinitiation system for polymer synthesis by employing a combination of riboflavin 5′-monophosphate sodium salt (vitamin B2) and hydrogen peroxide, and later a glucose/glucose oxidase system, for conducting reversible addition–fragmentation chain transfer (RAFT) polymerization. Under blue LED irradiation (λ = 451 nm), the bioactive form of riboflavin, flavin mononucleotide (FMN), in the presence of hydrogen peroxide was able to initiate the controlled RAFT polymerization of N,N-dimethylacrylamide. The resulting polymer was found to also possess excellent chain fidelity after chain extension via characterization by GPC. The photopolymerization was found to reach a higher conversion in the presence of hydrogen peroxide than without. This feature was exploited by using a glucose/glucose oxidase mixture to produce hydrogen peroxide in situ during the photopolymerization while additionally introducing oxygen tolerance into the system. These results suggest the excellent potential for this mild and oxygen tolerant bio-photo-Fenton photoinitiation system to be applied.

中文翻译：

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蓝光下的 Bio-photo-Fenton 样 RAFT 聚合


在这份手稿中，我们报道了一种用于聚合物合成的天然光引发系统，该系统采用核黄素 5'-单磷酸钠盐（维生素 B2）和过氧化氢的组合，然后是葡萄糖/葡萄糖氧化酶系统，用于进行可逆加成-碎裂链转移 （RAFT） 聚合。在蓝色 LED 照射下 （λ = 451 nm），核黄素的生物活性形式黄素单核苷酸 （FMN） 在过氧化氢存在下能够引发 N，N-二甲基丙烯酰胺的受控 RAFT 聚合。通过 GPC 表征发现所得聚合物在链延伸后也具有出色的链保真度。发现在有过氧化氢存在的情况下，光聚合反应比没有过氧化氢时达到更高的转化率。利用这一特性，在光聚合过程中使用葡萄糖/葡萄糖氧化酶混合物原位产生过氧化氢，同时在系统中额外引入耐氧性。这些结果表明，这种温和且耐氧的生物光芬顿光引发系统具有极好的应用潜力。