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Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD
Redox Biology ( IF 10.7 ) Pub Date : 2024-10-03 , DOI: 10.1016/j.redox.2024.103388
Tianhua Hou, Laiyu Zhu, Yan Zhang, Ying Tang, Yun Gao, Shucheng Hua, Xinxin Ci, Liping Peng

Pyroptosis is an inflammatory form of regulated necrosis that has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the role of lipid peroxidation in pyroptosis and its underlying mechanisms in COPD remain unclear.

中文翻译:


xCT 降解触发的脂质过氧化导致 COPD 中 gasdermin D 介导的焦亡



细胞焦亡是调节性坏死的一种炎症形式,与慢性阻塞性肺病 (COPD) 的发病机制有关。然而,脂质过氧化在焦亡中的作用及其在 COPD 中的潜在机制仍不清楚。
更新日期:2024-10-03
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