The mechanism of thrombocytopenia during acute pulmonary hypertension (PH) decompensation may be partly due to platelet aggregation in the lung. Platelet aggregates in explanted lung from 16 lung transplant patients during acute PH decompensation with and without thrombocytopenia were identified by immunohistochemistry. Scanning electron microscopy (SEM) was performed. 7 explant lung controls without PH and thrombocytopenia were also examined. Compared with controls, the median number of platelet aggregates was higher in patients with acute PH decompensation with thrombocytopenia (19.4 [IQR 3.4–38.3] vs 147.5 [IQR 26.5–203.2]). SEM showed capillaries filled with platelet aggregates. Our study suggests that platelets may aggregate in the lungs during acute PH decompensation.

中文翻译：

---

重度失代偿性肺动脉高压肺毛细血管中的血小板聚集


急性肺动脉高压 （PH） 失代偿期间血小板减少症的机制可能部分是由于血小板在肺部聚集。通过免疫组化鉴定 16 例肺移植患者急性 PH 失代偿伴和不伴血小板减少症时外植肺中的血小板聚集体。进行扫描电子显微镜 （SEM）。还检查了 7 例无 PH 和血小板减少症的外植体肺对照。与对照组相比，急性 PH 失代偿伴血小板减少症患者的血小板聚集体中位数更高 （19.4 [IQR 3.4-38.3] vs 147.5 [IQR 26.5-203.2]）。SEM 显示毛细血管充满血小板聚集体。我们的研究表明，在急性 PH 失代偿期间，血小板可能会在肺部聚集。