Objectives Running is one of the most accessible forms of exercise, yet its suitability for adults with chronic low back pain (LBP) is unknown. This study assessed the efficacy and acceptability of running in adults with chronic LBP. Methods This two-arm parallel (1:1) individually randomised controlled trial allocated 40 participants (mean (SD) age: 33 (6) years, female: 50%) with non-specific chronic LBP to a 12-week intervention or waitlist control. The intervention was a progressive run–walk interval programme comprising three 30-min sessions per week that were digitally delivered and remotely supported by an exercise physiologist. Efficacy outcomes were self-reported pain intensity (100-point visual analogue scale) and disability (Oswestry Disability Index). Acceptability outcomes were attrition, adherence and adverse events. Results At 12-week follow-up, the intervention improved average pain intensity (mean net difference (95% CI): −15.30 (–25.33, –5.27) points, p=0.003), current pain intensity (−19.35 (–32.01, –6.69) points, p=0.003) and disability (−5.20 (–10.12, –0.24) points, P=0.038), compared with control. There was no attrition, and mean (SD) training adherence was 70% (20%; ie, 2.1 of 3 sessions per week). Nine non-serious adverse events deemed likely study-related were reported (lower limb injury/pain: n=7, syncope associated with an underlying condition: n=1, LBP: n=1). Conclusions A run–walk programme was considered an acceptable intervention by the participants to improve the pain intensity and disability in individuals aged 18–45 years with non-specific chronic LBP when compared with the control. An individualised and conservative run–walk programme should be considered a suitable form of physical activity for adults with chronic LBP. Trial registration number Australian New Zealand Clinical Trials Registry: ACTRN12622001276741. Registered on 29 September 2022. Data are available upon reasonable request. The datasets used and analysed during the current study are available from the corresponding author on reasonable request.

中文翻译：

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跑步在患有非特异性慢性腰痛的成人中是可以接受和有效的：ASTEROID 随机对照试验


目标 跑步是最容易获得的运动形式之一，但其是否适合患有慢性腰痛 （LBP） 的成年人尚不清楚。本研究评估了成人慢性 LBP 患者跑步的疗效和可接受性。方法 这项双臂平行 （1：1） 个体随机对照试验将 40 名患有非特异性慢性 LBP 的参与者 （平均 （SD） 年龄：33 （6） 岁，女性：50%） 分配到 12 周干预或候补名单对照。干预是一项渐进式跑步-步行间歇计划，包括每周 3 次 30 分钟的课程，由运动生理学家提供数字授课和远程支持。疗效结局是自我报告的疼痛强度 （100 分视觉模拟量表） 和残疾 （Oswestry 残疾指数）。可接受性结局是损耗、依从性和不良事件。结果 在 12 周的随访中，干预改善了平均疼痛强度 （平均净差 （95% CI）：-15.30 （-25.33， -5.27） 分，p=0.003）、当前疼痛强度 （-19.35 （-32.01， -6.69） 分，p = 0.003）和残疾 （-5.20 （-10.12， -0.24） 分，P = 0.038），与对照组相比。没有流失，平均 （SD） 训练依从性为 70% （20%;即每周 3 节课中的 2.1 节）。报告了 9 例被认为可能与研究相关的非严重不良事件 （下肢损伤/疼痛： n=7，与潜在疾病相关的晕厥： n=1，LBP： n=1）。结论 与对照组相比，参与者认为跑步-步行计划是一种可接受的干预措施，可以改善 18-45 岁非特异性慢性 LBP 患者的疼痛强度和残疾。个体化和保守的跑步-步行计划应被视为适合慢性 LBP 成人的身体活动形式。 试验注册号澳大利亚新西兰临床试验注册中心：ACTRN12622001276741。于 2022 年 9 月 29 日注册。数据可根据合理要求提供。当前研究期间使用和分析的数据集可应合理要求从通讯作者处获得。