Detection of chiral molecules in a high-efficiency way is very important to meet the demands for chiral analysis in drug testing, asymmetric synthesis, etc. Herein, we have developed a novel route to realize the rapid determination of concentration and configuration of primary amine-based chiral molecules. An aldehyde functionalized acid & base-sensitive fluorane dye (R–C) was used as the active agent to be reacted with the chiral molecules through an aldimine condensation reaction. After the mixing operation, concentration and configuration of the detected chiral molecule could be facilely read from the UV-vis absorption spectra and CD spectra, respectively.

中文翻译：

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通过简单的醛二胺缩合反应高效检测伯胺基手性分子


高效检测手性分子对于满足药物检测、不对称合成等对手性分析的需求非常重要。在此，我们开发了一种新的途径来实现伯胺基手性分子浓度和构型的快速测定。醛功能化的酸碱敏感氟烷染料（R-C）被用作活性剂，通过醛胺缩合反应与手性分子反应。混合操作后，可以分别从 UV-vis 吸收光谱和 CD 光谱中轻松读取检测到的手性分子的浓度和构型。