The biomedical field is increasingly utilizing organic semiconducting materials, driving interest in the green synthesis of conjugated polymers from biomass-derived monomers. This study introduces an efficient C–H arylation method to synthesize furan-based conjugated polymers using oligofurans as building blocks. The resulting polymers exhibit excellent solubility and photostability, and as photosensitizers, they can generate singlet oxygen under both light and ultrasound excitation, effectively eradicating bacteria. Notably, long oligofurans demonstrate greater reactivity than individual furan monomers, which is crucial for producing high-molecular-weight furan-based conjugated polymers via direct C–H arylation. Moreover, adjusting the length of the oligofuran building blocks enables the tuning of the polymers’ bandgaps across the visible to near-infrared regions. This work presents a promising eco-friendly synthesis strategy for developing furan-based conjugated polymers with tailored properties for biomedical applications.

中文翻译：

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通过低聚呋喃的直接 C-H 芳基化合成具有可调带隙的呋喃基共轭聚合物


生物医学领域越来越多地利用有机半导体材料，推动了人们对从生物质衍生单体中绿色合成共轭聚合物的兴趣。本研究介绍了一种高效的 C-H 芳基化方法，以低聚呋喃为构建单元合成基于呋喃的共轭聚合物。所得聚合物表现出优异的溶解度和光稳定性，作为光敏剂，它们可以在光和超声激发下产生单线态氧，有效根除细菌。值得注意的是，长低聚呋喃比单个呋喃单体表现出更高的反应性，这对于通过直接 C-H 芳基化生产高分子量呋喃基共轭聚合物至关重要。此外，调整低聚呋喃结构单元的长度可以调整聚合物在可见光到近红外区域的带隙。这项工作提出了一种有前途的环保合成策略，用于开发具有定制特性的呋喃基共轭聚合物，用于生物医学应用。