Physiotherapies play a crucial role in noninvasive tissue engineering for wound healing. However, challenges such as the implementation of complex interventions and unsatisfactory treatment outcomes impede widespread application. Here, we proposed a stretchable and wirelessly-powered optoelectronic synergistic patch with a dual-layer serpentine wireless receiver circuit to drive the optoelectronic modulation component. Optimized structure and impedance matching enable the patch to seamlessly attach to irregular skin surfaces and operate robustly over a 30% tensile strain range. Based on Sprague-Dawley rat wound model. The wound closure rate of the optoelectronic synergistic group significantly outperformed both monointervention and blank control groups. Mechanistically, optoelectronic synergistic intervention enhances the secretion of vascular endothelial marker proteins and growth factors, and stabilizes mitochondrial function during oxidative stress. Overall, the scalable amalgamation of flexible electronics, wireless transmission, and synergistic interventions promise to improve wound care.

物理疗法在伤口愈合的无创组织工程中发挥着至关重要的作用。然而，复杂干预措施的实施和治疗结果不理想等挑战阻碍了广泛应用。在这里，我们提出了一种可拉伸且无线供电的光电协同贴片，具有双层蛇形无线接收器电路来驱动光电调制组件。优化的结构和阻抗匹配使贴片能够无缝附着到不规则的皮肤表面，并在 30% 的拉伸应变范围内稳定运行。基于 Sprague-Dawley 大鼠伤口模型。光电协同组的伤口闭合率显着优于单一干预组和空白对照组。从机制上讲，光电协同干预增强血管内皮标志蛋白和生长因子的分泌，并稳定氧化应激期间的线粒体功能。总体而言，柔性电子设备、无线传输和协同干预措施的可扩展融合有望改善伤口护理。