Mass spectrometry is a powerful method to study protein complexes; however, biochemical reactions are typically beyond the scope of MS studies. Here, we have studied the gas-phase redox chemistry of the [copper(II) – amyloid β] complex and show that the sequence-dependence of this chemistry reflects key aspects of the known in vitro behaviour of different variants of the peptide.

中文翻译：

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质谱法反映了铜-淀粉样蛋白 β 化学的关键方面


质谱分析是研究蛋白质复合物的一种强大方法。然而，生化反应通常超出了质谱研究的范围。在这里，我们研究了[铜( II )-淀粉样蛋白β]复合物的气相氧化还原化学，并表明这种化学的序列依赖性反映了肽不同变体已知体外行为的关键方面。