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Effect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics
Redox Biology ( IF 10.7 ) Pub Date : 2024-10-01 , DOI: 10.1016/j.redox.2024.103378
Belem Yoval-Sánchez, Ivan Guerrero, Fariha Ansari, Zoya Niatsetskaya, Max Siragusa, Jordi Magrane, Vadim Ten, Csaba Konrad, Marten Szibor, Alexander Galkin

Alternative oxidase (AOX) is an enzyme that transfers electrons from reduced quinone directly to oxygen without proton translocation. When AOX from Ciona intestinalis is xenotopically expressed in mice, it can substitute the combined electron-transferring activity of mitochondrial complexes III/IV. Here, we used brain mitochondria from AOX-expressing mice with such a chimeric respiratory chain to study respiratory control bioenergetic mechanisms.

中文翻译:


替代氧化酶 (AOX) 表达对小鼠脑线粒体生物能量学的影响



替代氧化酶 (AOX) 是一种将电子从还原醌直接转移到氧气而不会质子易位的酶。当来自 Ciona intestinalis 的 AOX 在小鼠中异位表达时,它可以替代线粒体复合物 III/IV 的组合电子转移活性。在这里,我们使用了来自具有这种嵌合呼吸链的 AOX 表达小鼠的脑线粒体来研究呼吸控制生物能量机制。
更新日期:2024-10-01
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