Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid Embase, and Web of Science databases, identifying 54 studies for inclusion. Comparisons included: (i) active IBD versus healthy controls; (ii) inactive IBD versus healthy controls; (iii) active CD versus inactive CD; and (iv) active UC versus inactive UC. Our analysis revealed a significant accumulation of biomarkers of oxidative damage to biomacromolecules, coupled with reductions in various antioxidants, in both patients with active and inactive IBD compared to healthy controls. Additionally, we identified biomarkers that differentiate between active and inactive CD, including malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity. Similarly, levels of Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC. Vitamins and carotenoids also emerged as potential disease activity biomarkers for CD and UC, but their intake should be monitored to obtain meaningful results. These findings emphasize the involvement of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers as a minimally invasive and additional tool for monitoring the activity of IBD.

中文翻译：

---

氧化应激相关生物标志物作为炎症性肠病活动的有前途指标：系统评价和荟萃分析


氧化应激被认为在炎症性肠病 （IBD） 的发病机制中起重要作用，特别是克罗恩病 （CD） 和溃疡性结肠炎 （UC）。本荟萃分析旨在识别和量化 IBD 中与氧化应激相关的生物标志物及其与疾病活动的关联。我们系统检索了Ovid MEDLINE、Ovid Embase和Web of Science数据库，确定了54项纳入的研究。比较包括：（i） 活动性 IBD 与健康对照;（ii） 非活动性 IBD 与健康对照;（iii） 活动性 CD 与非活动性 CD;（iv） 活动性 UC 与非活动性 UC。我们的分析显示，与健康对照相比，活动性和非活动性 IBD 患者对生物大分子的氧化损伤生物标志物的显着积累，以及各种抗氧化剂的减少。此外，我们确定了区分活性和非活性 CD 的生物标志物，包括丙二醛、对氧磷酶 1、过氧化氢酶、白蛋白、转铁蛋白和总抗氧化能力。同样，对氧磷酶 1 、红细胞谷胱甘肽过氧化物酶、过氧化氢酶、白蛋白、转铁蛋白和游离硫醇的水平在活性和非活性 UC 之间有所不同。维生素和类胡萝卜素也成为 CD 和 UC 的潜在疾病活动生物标志物，但应监测它们的摄入量以获得有意义的结果。这些发现强调了氧化应激与 IBD 发病机制的关系，并强调了氧化应激相关生物标志物作为监测 IBD 活性的微创和附加工具的潜力。