Keeping immune responses in an off state in the absence of a threat is essential to avoid the deleterious consequences of autoimmunity, while their timely activation upon perception of non-self determines the capacity of an organism to defend against potential pathogens. In plants, constitutive or untimely activation of immune responses dramatically limits growth and reproduction, highlighting the essential role of negative regulators of immunity for plant fitness. While a number of such regulators have been identified in the past couple of decades, the full complexity of the molecular mechanisms deployed by plants to ensure an appropriately controlled activation of immune responses, as well as their coordination with growth and development, are still largely elusive.

中文翻译：

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植物免疫制图：邻近标记将一种新的 SGT1-NSL1 调控模块放在地图上


在没有威胁的情况下将免疫反应保持在关闭状态对于避免自身免疫的有害后果至关重要，而它们在感知到非自我时及时激活决定了生物体抵御潜在病原体的能力。在植物中，免疫反应的组成性或不及时激活极大地限制了生长和繁殖，突出了免疫负调节因子对植物适应性的重要作用。虽然在过去几十年中已经确定了许多这样的调节因子，但植物为确保适当控制免疫反应的激活以及它们与生长和发育的协调而部署的分子机制的全部复杂性在很大程度上仍然难以捉摸。