Our approaches toward understanding cancer have evolved beyond cell-intrinsic and local microenvironmental changes within the tumor to encompass how the cancer interfaces with the entire host organism. The nervous system is uniquely situated at the interface between the brain and body, constantly receiving and sending signals back and forth to maintain homeostasis and respond to salient stimuli. It is becoming clear that various cancers disrupt this dialog between the brain and body via both neuronal and humoral routes, leading to aberrant brain activity and accelerated disease. In this outlook, I discuss this view of cancer as a homeostatic challenge, emphasize cutting-edge work, and provide outstanding questions that need to be answered to move the field forward.

中文翻译：

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脑-身体界面的癌症神经科学


我们理解癌症的方法已经超越了肿瘤内细胞内在和局部微环境的变化，涵盖了癌症如何与整个宿主生物体相互作用。神经系统独特地位于大脑和身体之间的界面，不断来回接收和发送信号以维持体内平衡并对显着刺激做出反应。越来越明显的是，各种癌症通过神经元和体液途径破坏了大脑和身体之间的这种对话，导致大脑活动异常和疾病加速。在这份展望中，我讨论了这种将癌症视为稳态挑战的观点，强调了前沿工作，并提供了需要回答的突出问题，以推动该领域向前发展。