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Temperature matters: the potential impact of thermoregulatory mechanisms in brain–body physiology
Genes & Development ( IF 7.5 ) Pub Date : 2024-09-01 , DOI: 10.1101/gad.352294.124 Elizabeth A. Repasky, Bonnie L. Hylander, Hemn Mohammadpour
Genes & Development ( IF 7.5 ) Pub Date : 2024-09-01 , DOI: 10.1101/gad.352294.124 Elizabeth A. Repasky, Bonnie L. Hylander, Hemn Mohammadpour
Thermoregulation, responsible for maintaining a stable core temperature during wide fluctuations in external and internal thermal environments, is an iconic homeostatic process. However, we suggest that despite its fundamental physiological significance, the potential for required cool housing temperatures and thermoregulatory mechanisms to influence the interpretation of experimental data is not sufficiently appreciated. Moreover, although it is generally assumed that the major thermoregulatory pathways are well understood, here we discuss new research that suggests otherwise and reveals the emergence of a new wave of exciting ideas for this “old” field of research.
中文翻译:
温度很重要:体温调节机制对脑-身体生理学的潜在影响
温度调节负责在外部和内部热环境的大幅波动期间保持稳定的核心温度,是一个标志性的稳态过程。然而,我们认为,尽管具有基本的生理意义,但所需的凉爽外壳温度和体温调节机制影响实验数据解释的可能性尚未得到充分认识。此外,尽管通常假设主要的体温调节途径已得到很好的理解,但在这里我们讨论的新研究表明并非如此,并揭示了这个“旧”研究领域出现了新一波令人兴奋的想法。
更新日期:2024-09-01
中文翻译:
温度很重要:体温调节机制对脑-身体生理学的潜在影响
温度调节负责在外部和内部热环境的大幅波动期间保持稳定的核心温度,是一个标志性的稳态过程。然而,我们认为,尽管具有基本的生理意义,但所需的凉爽外壳温度和体温调节机制影响实验数据解释的可能性尚未得到充分认识。此外,尽管通常假设主要的体温调节途径已得到很好的理解,但在这里我们讨论的新研究表明并非如此,并揭示了这个“旧”研究领域出现了新一波令人兴奋的想法。